Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962067 | 1.00 | PTGS2 (0.39) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL22019851 | 0.90 | PTGS2 (0.41) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL22020092 | 0.90 | PTGS2 (0.41) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL25067127 | 0.85 | PTGS2 (0.36) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL25033861 | 0.85 | PTGS2 (0.36) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL20698783 | 0.83 | PTGS2 (0.48) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL20681350 | 0.81 | PTGS2 (0.38) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL25033906 | 0.79 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL21963236 | 0.79 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL22019805 | 0.79 | PTGS2 (0.34) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880658-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | Novartis AG (CH) | 2021-09-22 | — | — | EP | disclosed |
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |