Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.39 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199322 | 0.82 | CYP19A1 (0.47) | SMN1; SMN2TSHRBRD4LMNAL3MBTL1 | |
| SCHEMBL2198089 | 0.81 | NPC1 (0.47) | SMN1; SMN2TSHRBRD4LMNAL3MBTL1 | |
| SCHEMBL2197221 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRBRD4LMNAL3MBTL1 | |
| SCHEMBL13351619 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHRBRD4LMNAL3MBTL1 | |
| SCHEMBL2195317 | 0.73 | ADORA3 (0.42) | SMN1; SMN2TSHRBRD4LMNAL3MBTL1 | |
| SCHEMBL23302623 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAGAAMAPTKDM4E | |
| SCHEMBL11632311 | 0.69 | GAA (0.66) | SMN1; SMN2TSHRLMNAL3MBTL1GAA | |
| SCHEMBL11629773 | 0.69 | SMN1; SMN2 (0.62) | SMN1; SMN2TSHRLMNAL3MBTL1GAA | |
| SCHEMBL1242879 | 0.69 | SMN1; SMN2 (0.87) | SMN1; SMN2TSHRBRD4LMNAL3MBTL1 | |
| SCHEMBL15647693 | 0.68 | SMN1; SMN2 (0.61) | SMN1; SMN2TSHRLMNAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998983-B2 | 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethysilylisoxazole; crop protection agents to combat or prevent fungal infestations, or to control other pests such as weeds, insects, or acarids | SYNGENTA LIMITED (GB) | 2011-08-16 | — | — | US | disclosed |
| US-7998983-B2 | 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethysilylisoxazole; crop protection agents to combat or prevent fungal infestations, or to control other pests such as weeds, insects, or acarids | SYNGENTA LIMITED (GB) | 2011-08-16 | — | — | US | disclosed |
| US-7998983-B2 | 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethysilylisoxazole; crop protection agents to combat or prevent fungal infestations, or to control other pests such as weeds, insects, or acarids | SYNGENTA LIMITED (GB) | 2011-08-16 | — | — | US | disclosed |
| US-7977341-B2 | For crops; 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethylsilylisoxazole for example | SYNGENTA LIMITED (GB) | 2011-07-12 | — | — | US | disclosed |
| US-7977341-B2 | For crops; 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethylsilylisoxazole for example | SYNGENTA LIMITED (GB) | 2011-07-12 | — | — | US | disclosed |
| US-7977341-B2 | For crops; 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethylsilylisoxazole for example | SYNGENTA LIMITED (GB) | 2011-07-12 | — | — | US | disclosed |
| US-20100179059-A1 | Fungicidal Mixtures | BASF SE (DE) | 2010-07-15 | — | — | US | disclosed |
| US-20100179059-A1 | Fungicidal Mixtures | BASF SE (DE) | 2010-07-15 | — | — | US | disclosed |
| US-20100179059-A1 | Fungicidal Mixtures | BASF SE (DE) | 2010-07-15 | — | — | US | disclosed |
| EP-2170071-A2 | FUNGICIDAL MIXTURES | BASF SE (DE) | 2010-04-07 | — | — | EP | disclosed |
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | SYNGENTA LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | SYNGENTA LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | SYNGENTA LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-7338967-B2 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2008-03-04 | — | — | US | disclosed |
| US-7338967-B2 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2008-03-04 | — | — | US | disclosed |
| US-7338967-B2 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2008-03-04 | — | — | US | disclosed |
| US-20060073971-A1 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2006-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | CYP4X1, CYP51A1, CYP3A7 | SMN1; SMN2 2136/4885TSHR 3322/4885BRD4 3927/4885 |
| US-20100179059-A1 | Fungicidal Mixtures | ARSA, AADAC, TYR | SMN1; SMN2 3779/4885TSHR 1135/4885BRD4 1854/4885 |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | CYP4X1, CYP51A1, CYP3A7 | SMN1; SMN2 2387/4885TSHR 3268/4885BRD4 3717/4885 |
| US-20060073971-A1 | Substituted isoxazoles as fungicides | CYP4X1, CYP51A1, CYP3A7 | SMN1; SMN2 2646/4885TSHR 3641/4885BRD4 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.