Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21960356 | 0.86 | ALDH1A1 (0.41) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL21960851 | 0.81 | MAP3K14 (0.39) | MAP3K14BRD4 | |
| SCHEMBL21964580 | 0.79 | BRD4 (0.40) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL23880180 | 0.79 | ALDH1A1 (0.48) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL6476531 | 0.77 | BAZ2B (0.42) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL17796618 | 0.70 | BRD4 (0.40) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL21960887 | 0.70 | BRD4 (0.43) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL21960873 | 0.69 | KMT2A (0.35) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL25509745 | 0.69 | HTT (0.43) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL25313659 | 0.69 | HTT (0.43) | MEN1KMT2ALMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |