Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 5/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21960873 | 0.85 | KMT2A (0.35) | CNR1CNR2MEN1ALDH1A1MAPT | |
| SCHEMBL23880197 | 0.84 | OPRM1 (0.35) | CNR1CNR2MEN1ALDH1A1MAPT | |
| SCHEMBL21964597 | 0.79 | MEN1 (0.39) | BRD4MAP3K14MEN1ALDH1A1MAPT | |
| SCHEMBL21960928 | 0.78 | ACHE (0.36) | MEN1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL21961362 | 0.77 | BAZ2B (0.40) | BRD4BAZ2BMAP3K14MALT1MEN1 | |
| SCHEMBL6476528 | 0.76 | BAZ2B (0.58) | BRD4BAZ2BMALT1MEN1ALDH1A1 | |
| SCHEMBL21964565 | 0.75 | ACHE (0.34) | DRD2 | |
| SCHEMBL21960888 | 0.73 | BAZ2B (0.39) | BRD4BAZ2BMAP3K14MEN1ALDH1A1 | |
| SCHEMBL21960851 | 0.72 | MAP3K14 (0.39) | BRD4BAZ2BCNR1CNR2MAP3K14 | |
| SCHEMBL21964581 | 0.72 | SMN1; SMN2 (0.35) | MAP3K14MEN1MAPTKMT2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |