Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551899 | 0.79 | NPC1 (0.47) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL936135 | 0.79 | RAF1 (0.46) | RAF1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL9285104 | 0.79 | RAF1 (0.43) | RAF1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL11062000 | 0.78 | RAF1 (0.42) | RAF1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL11061853 | 0.78 | RAF1 (0.42) | RAF1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL11201546 | 0.78 | RAF1 (0.42) | RAF1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL12982749 | 0.77 | RAF1 (0.42) | RAF1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL11411176 | 0.77 | RAF1 (0.45) | RAF1TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL8165575 | 0.76 | NR4A2 (0.47) | NR4A2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3228979 | 0.76 | TDP1 (0.46) | NR4A2TAS1R3TAS1R1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200140456-A1 | N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200140456-A1 | N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION | CRBN, CBL, STUB1 | NR4A2 857/4885RAF1 890/4885TAS1R3 4400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.