Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5288288 | 0.82 | LMNA (0.46) | NPC1RAB9ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL1644887 | 0.82 | ALDH1A1 (0.50) | NPC1RAB9AL3MBTL1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL11523814 | 0.80 | IDO1 (0.42) | NPC1PABPC1RAB9AL3MBTL1NFE2L2 | |
| SCHEMBL1114390 | 0.80 | KMT2A (0.45) | NPC1RAB9ANFE2L2BRD4LMNA | |
| SCHEMBL21965754 | 0.79 | NR4A2 (0.43) | NPC1RAB9AL3MBTL1NFE2L2SMN1; SMN2 | |
| SCHEMBL18540802 | 0.79 | IDO1 (0.49) | SMN1; SMN2LMNAMEN1KMT2APOLB | |
| SCHEMBL12730445 | 0.79 | ALDH1A1 (0.42) | NPC1RAB9AL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL2089084 | 0.78 | SMN1; SMN2 (0.47) | NPC1PABPC1RAB9AL3MBTL1NFE2L2 | |
| SCHEMBL8029352 | 0.76 | NPC1 (0.45) | NPC1PABPC1RAB9AL3MBTL1NFE2L2 | |
| SCHEMBL2089081 | 0.76 | NPC1 (0.45) | NPC1PABPC1RAB9AL3MBTL1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780245-A | SEROTONIN AGONISTS AND ANTAGONISTS; TREATMENT OF CARDIOVASCULAR DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-07-14 | — | — | US | disclosed |
| EP-0665885-A1 | POLYPEPTIDES (5HT2C) HAVING A SEROTONINERGIC RECEPTOR ACTIVITY AND USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994009130-A1 | POLYPEPTIDES (5HT2C) HAVING A SEROTONINERGIC RECEPTOR ACTIVITY AND USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1994-04-28 | — | — | WO | disclosed |