Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 12/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.48 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.48 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16194622 | 1.00 | GRM5 (0.56) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL16194566 | 0.90 | CHRNB2 (0.56) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL21968985 | 0.90 | CHRNB2 (0.56) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL21968841 | 0.90 | CHRNB2 (0.65) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL14941722 | 0.90 | CHRNB2 (0.65) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL16194984 | 0.90 | CHRNB2 (0.65) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL21968838 | 0.90 | CHRNB2 (0.55) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL16194582 | 0.90 | CHRNB2 (0.55) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL3358853 | 0.89 | CHRNB2 (0.52) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 | |
| SCHEMBL14941763 | 0.88 | CHRNB2 (0.58) | GRM5CHRNB2CHRNA4CHRNA3CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776423-B1 | PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2020-05-06 | — | — | EP | disclosed |