Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | UGCG | Q16739 | 1/20 | 0.34 |
| ▸ | PRF1 | P14222 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21970089 | 0.86 | DPP4 (0.45) | DPP4GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL21903321 | 0.82 | DPP4 (0.40) | DPP4GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL21903212 | 0.81 | PRF1 (0.40) | UGCGPRF1 | |
| SCHEMBL29986188 | 0.81 | PRF1 (0.40) | UGCGPRF1 | |
| SCHEMBL21903324 | 0.79 | GABRG2 (0.39) | DPP4GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL21971002 | 0.78 | LMNA (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL21903242 | 0.77 | MAP3K5 (0.45) | MKNK1UGCGPRF1 | |
| SCHEMBL21903271 | 0.77 | PRF1 (0.43) | PRF1 | |
| SCHEMBL29986096 | 0.77 | MAP3K5 (0.45) | MKNK1UGCGPRF1 | |
| SCHEMBL29987025 | 0.77 | PRF1 (0.43) | PRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200140438-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS | DOMAIN THERAPEUTICS (FR) | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200140438-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS | GRM3, GRM1, GRM2 | DPP4 3299/4885GABRG2 37/4885GABRB3 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.