Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661208 | 0.82 | CYP2D6 (0.36) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL21970960 | 0.82 | MME (0.33) | MME | |
| SCHEMBL21661015 | 0.82 | CYP2D6 (0.36) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL18052166 | 0.78 | KDM4E (0.42) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL23866602 | 0.77 | CYP2D6 (0.38) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL23866605 | 0.77 | CYP2D6 (0.38) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL21661207 | 0.77 | CYP2D6 (0.38) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL23866613 | 0.75 | CYP2C19 (0.40) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL22519377 | 0.75 | CYP2C19 (0.40) | POLBKDM4EEPHX1CYP2D6CYP2C19 | |
| SCHEMBL18084533 | 0.75 | KDM4E (0.35) | POLBKDM4EEPHX1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3270903-B1 | DISULFIDE-CONTAINING ALKYNE LINKING AGENTS | ARROWHEAD PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |