Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18087338 | 0.84 | CYP2C19 (0.33) | CYP2C19 | |
| SCHEMBL19543282 | 0.79 | — | — | |
| SCHEMBL19543482 | 0.78 | SPHK1 (0.41) | EPHX1 | |
| SCHEMBL15268891 | 0.76 | CHRM2 (0.36) | — | |
| SCHEMBL23366120 | 0.75 | — | — | |
| SCHEMBL17662375 | 0.75 | PAOX (0.35) | — | |
| SCHEMBL21970964 | 0.75 | POLB (0.42) | KDM4EPOLBEPHX1CYP2D6CYP2C19 | |
| SCHEMBL17662468 | 0.75 | TSHR (0.32) | KDM4E | |
| SCHEMBL10072896 | 0.73 | — | — | |
| SCHEMBL14638747 | 0.72 | NPSR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3270903-B1 | DISULFIDE-CONTAINING ALKYNE LINKING AGENTS | ARROWHEAD PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |
| US-20180023084-A1 | Disulfide-Containing Alkyne Linking Agents | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2018-01-25 | — | — | US | disclosed |
| US-9803201-B2 | Disulfide-containing alkyne linking agents | Arrowhead Pharmaceuticals, Inc. (US) | 2017-10-31 | — | — | US | disclosed |
| US-9803201-B2 | Disulfide-containing alkyne linking agents | Arrowhead Pharmaceuticals, Inc. (US) | 2017-10-31 | — | — | US | disclosed |
| US-20160272971-A1 | Disulfide-Containing Alkyne Linking Agents | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2016-09-22 | — | — | US | disclosed |