Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 5/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.42 |
| ▸ | PIK3R2 | O00459 | 5/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | PIK3R5 | Q8WYR1 | 5/20 | 0.42 |
| ▸ | PIK3R3 | Q92569 | 5/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | ACACA | Q13085 | 2/20 | 0.41 |
| ▸ | CBX7 | O95931 | 1/20 | 0.41 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.41 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.41 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197341 | 0.88 | MKNK1 (0.51) | EIF4EMKNK1MKNK2PIK3CDACACB | |
| SCHEMBL2201258 | 0.81 | ALDH1A1 (0.42) | EIF4EMKNK1MKNK2MEN1KMT2A | |
| SCHEMBL3689666 | 0.80 | POLR1A (0.41) | EIF4EMKNK1MKNK2CBX7CDYL2 | |
| SCHEMBL2201674 | 0.79 | DRD3 (0.40) | EIF4EMKNK1MKNK2MEN1KMT2A | |
| SCHEMBL2202074 | 0.79 | ALDH1A1 (0.47) | MKNK1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL2200712 | 0.78 | GRIN2B (0.44) | EIF4EMKNK1MKNK2MEN1KMT2A | |
| SCHEMBL2199010 | 0.77 | KDM4E (0.45) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2203144 | 0.73 | MAPT (0.50) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL2201254 | 0.69 | ALDH1A1 (0.41) | EIF4EMKNK1MKNK2MEN1KMT2A | |
| SCHEMBL2230472 | 0.69 | POLR1A (0.41) | EIF4EMKNK1MKNK2CBX7CDYL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2182953-A2 | NEW PYRAZOL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
| WO-2009013211-A2 | NEW PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | EIF4E 3310/4885MKNK1 3166/4885MKNK2 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.