Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRND | Q07001 | 1/20 | 0.31 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19592264 | 0.88 | RAF1 (0.33) | — | |
| SCHEMBL18600079 | 0.80 | CTSB (0.32) | — | |
| SCHEMBL171179 | 0.80 | CYP2A6 (0.33) | GRM5CYP2A6CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL9918235 | 0.78 | GRM5 (0.32) | GRM5CYP2A6CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL22931080 | 0.77 | CYP2A6 (0.33) | GRM5CYP2A6CHRNA1CHRNB4CHRNA3 | |
| SCHEMBL19592358 | 0.77 | PBRM1 (0.35) | GRM5 | |
| SCHEMBL19592420 | 0.76 | CYP19A1 (0.37) | — | |
| SCHEMBL21975098 | 0.75 | CYP11B1 (0.35) | — | |
| SCHEMBL13774815 | 0.74 | GRM5 (0.30) | GRM5CYP2A6 | |
| SCHEMBL12329945 | 0.74 | CTSL (0.32) | GRM5CYP2A6CHRNA3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343298-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2020-05-06 | — | — | EP | disclosed |