Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | TEK | Q02763 | 4/20 | 0.57 |
| ▸ | YES1 | P07947 | 3/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.56 |
| ▸ | LCK | P06239 | 5/20 | 0.56 |
| ▸ | ABL1 | P00519 | 4/20 | 0.56 |
| ▸ | BCR | P11274 | 4/20 | 0.56 |
| ▸ | BRAF | P15056 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 4/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | ESYT2 | A0FGR8 | 2/20 | 0.56 |
| ▸ | NBAS | A2RRP1 | 2/20 | 0.56 |
| ▸ | CNOT1 | A5YKK6 | 2/20 | 0.56 |
| ▸ | TBKBP1 | A7MCY6 | 2/20 | 0.56 |
| ▸ | AGPS | O00116 | 2/20 | 0.56 |
| ▸ | MYO1F | O00160 | 2/20 | 0.56 |
| ▸ | SNAP23 | O00161 | 2/20 | 0.56 |
| ▸ | AP3B1 | O00203 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21974992 | 0.94 | KDR (0.49) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL21975688 | 0.89 | ABL1 (0.45) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL22066074 | 0.83 | BRAF (0.61) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL21943344 | 0.81 | PIKFYVE (0.62) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL21943601 | 0.81 | KDR (0.58) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL22066484 | 0.81 | MAPK14 (0.68) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL21943339 | 0.81 | BRAF (0.76) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL21975119 | 0.80 | RET (0.39) | BRAFRETLMNAHSD17B10KIF5B | |
| SCHEMBL21943333 | 0.80 | KDR (0.61) | KDRTEKYES1MAPK14LCK | |
| SCHEMBL21975647 | 0.79 | ABCG2 (0.48) | KDRTEKYES1MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |
| US-9425409-B2 | Materials for electronic devices | MERCK PATENT GMBH (DE) | 2016-08-23 | — | — | US | disclosed |