Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | TEK | Q02763 | 6/20 | 0.49 |
| ▸ | YES1 | P07947 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 10/20 | 0.48 |
| ▸ | BCR | P11274 | 7/20 | 0.48 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 3/20 | 0.48 |
| ▸ | STK10 | O94804 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.48 |
| ▸ | LYN | P07948 | 3/20 | 0.48 |
| ▸ | HCK | P08631 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | PHKG2 | P15735 | 3/20 | 0.48 |
| ▸ | NQO2 | P16083 | 3/20 | 0.48 |
| ▸ | EPHA1 | P21709 | 3/20 | 0.48 |
| ▸ | FECH | P22830 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21975658 | 0.94 | KDR (0.57) | KDRTEKYES1ABL1BCR | |
| SCHEMBL21975688 | 0.89 | ABL1 (0.45) | KDRTEKYES1ABL1BCR | |
| SCHEMBL21975119 | 0.82 | RET (0.39) | RETBRAFLMNAHSD17B10KIF5B | |
| SCHEMBL21943600 | 0.80 | ABL1 (0.67) | KDRTEKYES1ABL1BCR | |
| SCHEMBL21974774 | 0.80 | RET (0.71) | ABL1BCRRETLCKLYN | |
| SCHEMBL22066074 | 0.78 | BRAF (0.61) | KDRTEKYES1ABL1BCR | |
| SCHEMBL21975103 | 0.77 | CYP1A2 (0.41) | PRKCAMAPK1RECQLHSD17B10CLK4 | |
| SCHEMBL21975693 | 0.77 | LRRK2 (0.44) | TTK | |
| SCHEMBL21975115 | 0.76 | POLB (0.48) | RETLMNADYRK1AKIF5BCCDC6 | |
| SCHEMBL21975647 | 0.73 | ABCG2 (0.48) | KDRTEKYES1MAPK14PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |