Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21974762 | 0.84 | MAPT (0.44) | MAPTPOLBNPSR1RAB9ALMNA | |
| SCHEMBL21975659 | 0.78 | MAPT (0.37) | MAPTPOLBNPSR1LMNAABCG2 | |
| SCHEMBL21975103 | 0.71 | CYP1A2 (0.41) | MAPTPOLBNPSR1RAB9APRKCA | |
| SCHEMBL21975105 | 0.71 | MEN1 (0.40) | MAPTLMNASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL21974920 | 0.70 | ABCG2 (0.43) | MAPTPOLBNPSR1RAB9ALMNA | |
| SCHEMBL21975122 | 0.69 | RAB9A (0.41) | MAPTPOLBNPSR1RAB9AABL1 | |
| SCHEMBL22066072 | 0.68 | CYP3A4 (0.59) | MAPTNPSR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL21974789 | 0.67 | RAB9A (0.41) | MAPTPOLBNPSR1RAB9AABCG2 | |
| SCHEMBL21974781 | 0.66 | MAPT (0.40) | MAPTPOLBNPSR1LMNAABCG2 | |
| SCHEMBL21974948 | 0.66 | CYP11B1 (0.34) | MAPTPOLBABL1BCRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |