Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21975115 | 0.86 | POLB (0.48) | — | |
| SCHEMBL21975688 | 0.80 | ABL1 (0.45) | TTKMAPT | |
| SCHEMBL21975119 | 0.80 | RET (0.39) | MAPT | |
| SCHEMBL21943605 | 0.79 | BTK (0.47) | LRRK2HTTMAPT | |
| SCHEMBL21975103 | 0.79 | CYP1A2 (0.41) | HTTTTKMAPT | |
| SCHEMBL21974992 | 0.77 | KDR (0.49) | TTK | |
| SCHEMBL21975658 | 0.75 | KDR (0.57) | TTKMAPT | |
| SCHEMBL14727503 | 0.73 | MAPT (0.55) | LRRK2JAK2HTTMKNK2MAPT | |
| SCHEMBL14727501 | 0.72 | MAPT (0.51) | JAK2HTTMAPT | |
| SCHEMBL21942936 | 0.70 | RET (0.47) | HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3647313-A1 | SUBSTITUTED ARYL ETHER COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Xiamen University (CN) | 2020-05-06 | — | — | EP | disclosed |