Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976479 | 0.91 | HDAC6 (0.50) | HDAC6PARP10KDM1APKMMAPT | |
| SCHEMBL21976248 | 0.85 | HDAC6 (0.45) | HDAC6PARP10KDM1APKMMAPT | |
| SCHEMBL21976492 | 0.81 | SMPD1 (0.53) | HDAC6MAPTRAB9ASMPD1MEN1 | |
| SCHEMBL21976503 | 0.74 | MEN1 (0.45) | HDAC6MAPTMEN1KMT2AHDAC8 | |
| SCHEMBL21976308 | 0.74 | HDAC6 (0.51) | HDAC6SMPD1MEN1KMT2AHDAC8 | |
| SCHEMBL21976251 | 0.74 | HDAC6 (0.52) | HDAC6SMPD1HDAC8 | |
| SCHEMBL21976229 | 0.74 | GAA (0.46) | HDAC6KDM1AMAPTRAB9AMEN1 | |
| SCHEMBL21976963 | 0.72 | HDAC6 (0.49) | HDAC6SMPD1HDAC8 | |
| SCHEMBL21976203 | 0.72 | GAA (0.49) | HDAC6MAPTMEN1KMT2AHDAC8 | |
| SCHEMBL21976470 | 0.72 | HDAC6 (0.55) | HDAC6MEN1KMT2AHDAC8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |