Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976231 | 0.92 | HDAC6 (0.47) | HDAC6HDAC8PLAUHDAC1SMPD1 | |
| SCHEMBL21976203 | 0.87 | GAA (0.49) | HDAC6HDAC8HDAC1 | |
| SCHEMBL21976251 | 0.81 | HDAC6 (0.52) | HDAC6HDAC8PLAUHDAC1PARP1 | |
| SCHEMBL5943946 | 0.79 | HDAC6 (0.61) | HDAC6HDAC8PLAUHDAC1GRM5 | |
| SCHEMBL21975936 | 0.79 | MEN1 (0.42) | HDAC6HDAC8HDAC1MMP2MMP9 | |
| SCHEMBL21976309 | 0.77 | HDAC6 (0.41) | HDAC6HDAC8HDAC1 | |
| SCHEMBL21976503 | 0.74 | MEN1 (0.45) | HDAC6HDAC8HDAC1 | |
| SCHEMBL21976470 | 0.74 | HDAC6 (0.55) | HDAC6HDAC8HDAC1 | |
| SCHEMBL21976943 | 0.72 | HDAC8 (0.52) | HDAC6HDAC8HDAC1 | |
| SCHEMBL6674303 | 0.72 | KDM4E (0.62) | HDAC6HDAC8HDAC1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |