Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | EBP | Q15125 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282343 | 0.85 | POLB (0.61) | PKLRMEN1KMT2AABCB11TP53 | |
| SCHEMBL14282310 | 0.81 | S1PR2 (0.60) | PKLRMEN1KMT2AOPRL1OPRM1 | |
| SCHEMBL11521599 | 0.79 | PKLR (0.57) | PKLRMEN1KMT2AABCB11TP53 | |
| SCHEMBL2925749 | 0.79 | OPRM1 (0.63) | MEN1KMT2AABCB11TP53CYP3A4 | |
| SCHEMBL4186712 | 0.78 | PKLR (0.55) | PKLRMEN1KMT2AABCB11TP53 | |
| SCHEMBL1760977 | 0.78 | OPRL1 (0.62) | MEN1KMT2AABCB11TP53CYP3A4 | |
| SCHEMBL21976370 | 0.77 | PKLR (0.71) | PKLR | |
| SCHEMBL5912310 | 0.77 | GRIN2B (0.63) | OPRL1OPRM1CHRM4LMNA | |
| SCHEMBL28821627 | 0.77 | PKLR (0.49) | PKLROPRM1KDM4ERXFP1POLB | |
| SCHEMBL16049680 | 0.77 | PKLR (1.00) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |