Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 18/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976363 | 0.89 | PKLR (0.67) | PKLR | |
| SCHEMBL21977150 | 0.88 | PKLR (0.68) | PKLRALDH1A1LMNACA12CA1 | |
| SCHEMBL21975982 | 0.87 | PKLR (0.67) | PKLRALDH1A1LMNACA12CA1 | |
| SCHEMBL21976500 | 0.83 | PKLR (0.78) | PKLR | |
| SCHEMBL21976664 | 0.83 | PKLR (0.70) | PKLR | |
| SCHEMBL21976628 | 0.83 | PKLR (0.71) | PKLR | |
| SCHEMBL21976399 | 0.83 | PKLR (0.74) | PKLR | |
| SCHEMBL21976288 | 0.83 | PKLR (0.79) | PKLR | |
| SCHEMBL21977086 | 0.83 | PKLR (0.77) | PKLR | |
| SCHEMBL21976498 | 0.82 | PKLR (0.75) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |