Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 16/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976374 | 0.87 | PKLR (0.69) | PKLRCA12CA1CA2CA7 | |
| SCHEMBL21976363 | 0.83 | PKLR (0.67) | PKLR | |
| SCHEMBL21977150 | 0.82 | PKLR (0.68) | PKLRCA12CA1CA2CA7 | |
| SCHEMBL16084096 | 0.80 | PKLR (1.00) | PKLR | |
| SCHEMBL21975972 | 0.79 | PKLR (0.70) | PKLRALDH1A1LMNA | |
| SCHEMBL21976765 | 0.78 | ALDH1A1 (0.53) | PKLRCA12CA1CA2CA7 | |
| SCHEMBL21976235 | 0.75 | PKLR (0.69) | PKLR | |
| SCHEMBL21976239 | 0.75 | PKLR (0.70) | PKLR | |
| SCHEMBL21976318 | 0.74 | PKLR (0.70) | PKLR | |
| SCHEMBL21976183 | 0.74 | PKLR (0.72) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |