Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | MMP13 | P45452 | 2/20 | 0.55 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9295731 | 0.89 | MPL (0.67) | MPLHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL13599850 | 0.84 | NPC1 (0.81) | NPC1RAB9ANPBWR1MMP2MMP9 | |
| SCHEMBL13183701 | 0.82 | NPC1 (0.78) | NPC1RAB9ANPBWR1MMP2MMP9 | |
| SCHEMBL9095200 | 0.82 | MPL (0.63) | MPLHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL6544064 | 0.82 | MPL (0.59) | MPLHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9295738 | 0.82 | MPL (0.48) | MPLHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9295726 | 0.80 | MPL (0.57) | MPLHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3546177 | 0.79 | MPL (1.00) | MPLHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL18229675 | 0.78 | HDAC6 (1.00) | MPLHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL6124301 | 0.78 | NPC1 (0.71) | NPC1RAB9ANPBWR1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |