Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 6/20 | 0.43 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.39 |
| ▸ | MAT2A | P31153 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28388238 | 0.99 | TLR8 (0.47) | TLR8KDM1AGRM5GRM1MAT2A | |
| SCHEMBL24165818 | 0.89 | TLR8 (0.44) | TLR8KDM1AGRM5GRM1MAT2A | |
| SCHEMBL30659208 | 0.88 | TLR8 (0.48) | TLR8KCNH2HRH3 | |
| SCHEMBL22028267 | 0.88 | TLR8 (0.48) | TLR8KCNH2HRH3 | |
| SCHEMBL21979906 | 0.86 | HTT (0.43) | GRM5GRM1MAT2AHTTKCNH2 | |
| Hydrochloric Acid SCHEMBL21980096 | 0.85 | HTT (0.43) | GRM5GRM1MAT2AHTTKCNH2 | |
| SCHEMBL22028265 | 0.84 | TLR8 (0.44) | TLR8KDM1AGRM5GRM1MAT2A | |
| SCHEMBL22030636 | 0.84 | HTT (0.42) | TLR8KDM1AMAT2AHTTWNT1 | |
| SCHEMBL26976934 | 0.83 | TLR8 (0.40) | TLR8KDM1AGRM5GRM1MAT2A | |
| Hydrochloric Acid SCHEMBL28383603 | 0.83 | TLR8 (0.43) | TLR8KDM1AGRM5GRM1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634953-B1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-01-03 | — | — | EP | claimed |
| CN-111065626-A | Compounds for the treatment of huntington's chorea | PTC医疗公司 | 2020-04-24 | — | — | CN | claimed |
| US-12384789-B2 | Compounds for treating Huntington's disease | PTC THERAPEUTICS, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| EP-3634953-B1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-01-03 | — | — | EP | disclosed |
| EP-4151627-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2023-03-22 | — | — | EP | disclosed |
| US-20220251098-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. | 2022-08-11 | — | — | US | disclosed |
| US-11407753-B2 | Compounds for treating Huntington's disease | PTC THERAPEUTICS, INC. (US) | 2022-08-09 | — | — | US | disclosed |
| US-20200165256-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. | 2020-05-28 | — | — | US | disclosed |
| US-20200165256-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220251098-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | HTT, HYPK, FH | TLR8 4811/4885KDM1A 2674/4885GRM5 319/4885 |
| US-20200165256-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | HTT, HYPK, FH | TLR8 4811/4885KDM1A 2674/4885GRM5 319/4885 |
| US-11407753-B2 | Compounds for treating Huntington's disease | HTT, HYPK, FH | TLR8 4811/4885KDM1A 2674/4885GRM5 319/4885 |
| US-12384789-B2 | Compounds for treating Huntington's disease | HTT, HYPK, FH | TLR8 4811/4885KDM1A 2674/4885GRM5 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.