Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.73 |
| ▸ | RAB9A | P51151 | 10/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.61 |
| ▸ | RELA | Q04206 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366233 | 0.88 | NPC1 (0.72) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL11961607 | 0.84 | NPC1 (0.71) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL32681139 | 0.84 | NPC1 (1.00) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL15508206 | 0.81 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL30494024 | 0.80 | NPC1 (0.65) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL7306324 | 0.79 | NPC1 (0.78) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL8460943 | 0.78 | RAB9A (0.75) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL29618325 | 0.78 | KMT2A (0.71) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL7296050 | 0.77 | RAB9A (0.69) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL7301810 | 0.77 | KMT2A (0.67) | NPC1RAB9ANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647678-B2 | Quinoline derivatives as inhibitors of heat shock factor 1 pathway activity | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2020-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647678-B2 | Quinoline derivatives as inhibitors of heat shock factor 1 pathway activity | HSF1, HSP90AB1, HSP90AB2P | NPC1 2250/4885RAB9A 1649/4885NFKB1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.