Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 3/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | TAF1 | P21675 | 1/20 | 0.30 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19100535 | 0.78 | AHR (0.41) | AHRNR4A2NR3C1PGRCSNK2A1 | |
| SCHEMBL2599709 | 0.75 | AHR (0.45) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL21315701 | 0.74 | AHR (0.48) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL838245 | 0.74 | AHR (0.54) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL28992884 | 0.72 | AHR (0.42) | AHRF7LTA4HF3NR4A2 | |
| Tert-Butyl Formate SCHEMBL27584063 | 0.72 | TDP1 (0.37) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL18746334 | 0.71 | SMN1; SMN2 (0.51) | — | |
| SCHEMBL13961694 | 0.71 | AHR (0.45) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL1397681 | 0.71 | CSNK2A1 (0.46) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL14909105 | 0.71 | TNF (0.57) | AHRF7LTA4HF3NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647703-B2 | Inhibitors of KRAS G12C mutant proteins | ARAXES PHARMA LLC (US) | 2020-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647703-B2 | Inhibitors of KRAS G12C mutant proteins | KRAS, NRAS, G3BP1 | AHR 3864/4885F7 3279/4885LTA4H 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.