Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 3/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838245 | 0.82 | AHR (0.54) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL1397681 | 0.78 | CSNK2A1 (0.46) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL14909105 | 0.78 | TNF (0.57) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL13961694 | 0.78 | AHR (0.45) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL2599709 | 0.78 | AHR (0.45) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL28600170 | 0.78 | AHR (0.45) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL14363462 | 0.76 | GPR84 (0.34) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL26389475 | 0.76 | AHR (0.47) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL28992884 | 0.75 | AHR (0.42) | AHRF7LTA4HF3NR4A2 | |
| SCHEMBL25239348 | 0.74 | AHR (0.46) | AHRF7LTA4HF3NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3759227-A1 | IMPROVED METHOD FOR THE SYNTHESIS OF TRYPTOPHAN ANALOGS IN AQUEOUS SOLVENTS AT REDUCED TEMPERATURES | California Institute of Technology (US) | 2021-01-06 | — | — | EP | disclosed |
| US-10752927-B2 | Method for the synthesis of tryptophan analogs in aqueous solvents at reduced temperatures | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190271016-A1 | METHOD FOR THE SYNTHESIS OF TRYPTOPHAN ANALOGS IN AQUEOUS SOLVENTS AT REDUCED TEMPERATURES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-09-05 | — | — | US | disclosed |