SCHEMBL2599709

SCHEMBL2599709

Cc1cc(Cl)cc2cc[nH]c12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.45
F7 P08709 1/20 0.45
LTA4H P09960 1/20 0.45
F3 P13726 1/20 0.45
NR4A2 P43354 1/20 0.45
NR3C1 P04150 6/20 0.45
PGR P06401 6/20 0.45
TNF P01375 1/20 0.42
RIPK1 Q13546 1/20 0.42
CMA1 P23946 1/20 0.41
IKBKB O14920 2/20 0.38
CHUK O15111 2/20 0.38
HRH4 Q9H3N8 4/20 0.38
BRD4 O60885 1/20 0.36
TAF1 P21675 1/20 0.36
BRPF1 P55201 1/20 0.36
CREBBP Q92793 1/20 0.36
CECR2 Q9BXF3 1/20 0.36
BRD9 Q9H8M2 1/20 0.36
GRM5 P41594 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tert-Butyl Formate SCHEMBL27584063 0.83 TDP1 (0.37) AHRF7LTA4HF3NR4A2
Ethoxycarbonyl Group SCHEMBL27759816 0.82 NR3C1 (0.36) AHRF7LTA4HF3NR4A2
SCHEMBL838245 0.78 AHR (0.54) AHRF7LTA4HF3NR4A2
SCHEMBL21315701 0.78 AHR (0.48) AHRF7LTA4HF3NR4A2
SCHEMBL4798726 0.78 CYP1A2 (0.40) AHRNR3C1PGRIKBKBCHUK
SCHEMBL4484912 0.77 AHR (0.47) AHRNR3C1PGRTNFRIPK1
SCHEMBL28992884 0.76 AHR (0.42) AHRF7LTA4HF3NR4A2
SCHEMBL1397681 0.75 CSNK2A1 (0.46) AHRF7LTA4HF3NR4A2
SCHEMBL2983533 0.75 ALDH1A1 (0.38) AHRNR3C1PGRIKBKBCHUK
SCHEMBL28600170 0.75 AHR (0.45) AHRF7LTA4HF3NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116730859-B Preparation method of 2-amino-5-chloro-N, 3-dimethylbenzamide 青岛科技大学 2025-06-13 CN claimed
CN-117043148-A Process for preparing chlorantraniliprole 加尔达化学有限公司 2023-11-10 CN claimed
CN-116987002-A Preparation method of 2-amino-5-chloro-N, 3-dimethylbenzamide 湖北可赛化工有限公司 2023-11-03 CN claimed
CN-116730859-A Preparation method of 2-amino-5-chloro-N, 3-dimethylbenzamide 青岛科技大学 2023-09-12 CN claimed
CN-116730859-B Preparation method of 2-amino-5-chloro-N, 3-dimethylbenzamide 青岛科技大学 2025-06-13 CN disclosed
EP-3436004-B1 SUBSTITUTED INDOLE COMPOUND DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS JANSSEN PHARMACEUTICALS INC (US) 2024-12-11 EP disclosed
CN-117720426-A Synthesis method of 2-amino-5-chloro-3-methylbenzoic acid 湖北泰盛化工有限公司 2024-03-19 CN disclosed
CN-117043148-A Process for preparing chlorantraniliprole 加尔达化学有限公司 2023-11-10 CN disclosed
CN-116987002-A Preparation method of 2-amino-5-chloro-N, 3-dimethylbenzamide 湖北可赛化工有限公司 2023-11-03 CN disclosed
CN-116730859-A Preparation method of 2-amino-5-chloro-N, 3-dimethylbenzamide 青岛科技大学 2023-09-12 CN disclosed
CN-112778147-B Preparation method of 2-amino-3-methyl-5-chlorobenzoic acid 锦州三丰科技有限公司 2022-10-11 CN disclosed
EP-3988549-A1 MACROCYCLES WITH HETEROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS Bristol-Myers Squibb Company (US) 2022-04-27 EP disclosed
US-20120142735-A1 DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]- 1H-INDOL-3-YL]-METHANONES SANOFI (FR) 2012-06-07 US disclosed
US-20120142735-A1 DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]- 1H-INDOL-3-YL]-METHANONES SANOFI (FR) 2012-06-07 US disclosed
US-20120142735-A1 DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]- 1H-INDOL-3-YL]-METHANONES SANOFI (FR) 2012-06-07 US disclosed
CN-102470132-A Disubstituted [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones SANOFI AVENTIS 2012-05-23 CN disclosed
WO-2011146324-A1 SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS MERCK SHARP & DOHME CORP. (US) 2011-11-24 WO disclosed
WO-2011022449-A1 DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-1H-INDOL-3-YL]-METHANONES SANOFI-AVENTIS (FR) 2011-02-24 WO disclosed
US-20080267942-A1 BENZAZEPIN-2(1H)-ONE DERIVATIVES PFIZER LIMITED (GB) 2008-10-30 US disclosed
US-20080103130-A1 7-hydroxy-6-{[1-methyl-3-(1,3-thiazol-5-yl)propyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one; agonists at the beta-2 adrenoceptor; feed additives for livestock animals; improving meat yield or meat quality PFIZER LIMITED (GB) 2008-05-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142735-A1 DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]- 1H-INDOL-3-YL]-METHANONES CMA1, TPSB2, TPSAB1 AHR 647/4885F7 1045/4885LTA4H 231/4885
US-20080103130-A1 7-hydroxy-6-{[1-methyl-3-(1,3-thiazol-5-yl)propyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one; agonists at the beta-2 adrenoceptor; feed additives for livestock animals; improving meat yield or meat quality ADRB2, ADRB1, ADRA2C AHR 523/4885F7 918/4885LTA4H 2402/4885
US-20080267942-A1 BENZAZEPIN-2(1H)-ONE DERIVATIVES ADRB2, ADRB1, ADRA2C AHR 1267/4885F7 1791/4885LTA4H 2751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.