Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 8/20 | 0.41 |
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA12 | O43570 | 7/20 | 0.41 |
| ▸ | CA9 | Q16790 | 7/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523550 | 0.85 | TDP1 (0.55) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL23905247 | 0.85 | TDP1 (0.47) | TDP1MAOAMAOBMEN1GAA | |
| Hydrochloric Acid SCHEMBL2523548 | 0.84 | TDP1 (0.53) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL23745158 | 0.83 | TDP1 (0.49) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL15612944 | 0.82 | TDP1 (0.55) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL1164569 | 0.80 | TDP1 (0.58) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL21687368 | 0.80 | TDP1 (0.53) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL19155344 | 0.80 | TDP1 (0.68) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL28854600 | 0.80 | TDP1 (0.46) | TDP1MAOAMAOBMEN1GAA | |
| SCHEMBL21687743 | 0.79 | TDP1 (0.51) | TDP1MAOAMAOBMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647686-B2 | Substituted pyrimidines for preventing or treating cancer and inflammatory diseases | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2020-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647686-B2 | Substituted pyrimidines for preventing or treating cancer and inflammatory diseases | TGFBR1, TGFBR2, TGFB1 | TDP1 961/4885MAOA 4159/4885MAOB 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.