Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.45 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198201 | 0.90 | KCNA5 (0.45) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2197522 | 0.89 | CYP19A1 (0.37) | KCNA5KCND3MAPTSMN1; SMN2LMNA | |
| SCHEMBL2195309 | 0.87 | KCNA5 (0.45) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2195323 | 0.87 | KCNA5 (0.53) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2196236 | 0.85 | KCNA5 (0.43) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2198411 | 0.85 | KCNA5 (0.45) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2197727 | 0.85 | KCNA5 (0.48) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2197845 | 0.84 | KCNA5 (0.47) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2199030 | 0.83 | CYP2A6 (0.48) | KCNA5KCND3TP53POLBMAPT | |
| SCHEMBL2226643 | 0.82 | KCNA5 (0.42) | KCNA5KCND3TP53POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013007550-A1 | FUNGICIDE MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-17 | — | — | WO | disclosed |
| US-20110251066-A1 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-10-13 | — | — | US | disclosed |
| US-7998983-B2 | 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethysilylisoxazole; crop protection agents to combat or prevent fungal infestations, or to control other pests such as weeds, insects, or acarids | SYNGENTA LIMITED (GB) | 2011-08-16 | — | — | US | disclosed |
| US-7977341-B2 | For crops; 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethylsilylisoxazole for example | SYNGENTA LIMITED (GB) | 2011-07-12 | — | — | US | disclosed |
| WO-2010069881-A2 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | SYNGENTA LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-7338967-B2 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2008-03-04 | — | — | US | disclosed |
| US-20060073971-A1 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2006-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | CYP4X1, CYP51A1, CYP3A7 | KCNA5 850/4885KCND3 1175/4885TP53 4351/4885 |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | CYP4X1, CYP51A1, CYP3A7 | KCNA5 760/4885KCND3 1227/4885TP53 4452/4885 |
| US-20110251066-A1 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | CYP4Z1, CYP4X1, AGXT | KCNA5 1858/4885KCND3 2559/4885TP53 4733/4885 |
| US-20060073971-A1 | Substituted isoxazoles as fungicides | CYP4X1, CYP51A1, CYP3A7 | KCNA5 750/4885KCND3 1046/4885TP53 3359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.