SCHEMBL21985183

SCHEMBL21985183

CCC1CCC(=O)C(c2ccc(Br)cc2OC)C1=O

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.39
CA2 P00918 2/20 0.39
CA4 P22748 2/20 0.39
CA6 P23280 2/20 0.39
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
TSHR P16473 2/20 0.38
KDM4E B2RXH2 2/20 0.38
HTR2A P28223 2/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
TACR1 P25103 2/20 0.36
CCR5 P51681 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21985343 0.82 PPARD (0.33) CA1CA2CA4CA6HTR2A
SCHEMBL21985644 0.78 LMNA (0.31) TSHR
SCHEMBL11218191 0.76 CA1 (0.32) CA1CA2CA4CA6ALDH1A1
SCHEMBL17376651 0.73 KMT2A (0.40) ALDH1A1MEN1KMT2AKDM4EHTR2A
SCHEMBL21985266 0.73 ALDH1A1 (0.32) ALDH1A1MEN1KMT2ATSHRKDM4E
SCHEMBL21985356 0.71 HCRTR1 (0.33) MEN1KMT2A
SCHEMBL20060289 0.71 HTR2A (0.38) CA1CA2CA4CA6HTR2A
SCHEMBL20298470 0.70 KMT2A (0.43) ALDH1A1MEN1KMT2AKDM4ETDP1
SCHEMBL21938657 0.70 ALDH1A1 (0.39) CA2ALDH1A1MEN1KMT2AKDM4E
SCHEMBL21840205 0.70 ALDH1A1 (0.39) CA2ALDH1A1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3160950-B1 HERBICIDAL PROPYNYL-PHENYL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2020-05-13 EP disclosed