Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31132418 | 1.00 | KDM4E (0.65) | KDM4ECSNK1A1CLK4ADORA2AADORA1 | |
| SCHEMBL4864061 | 0.86 | HTT (0.60) | KDM4ECSNK1A1CLK4ADORA2AADORA1 | |
| SCHEMBL9775493 | 0.86 | KDM4E (0.58) | KDM4ECSNK1A1CLK4ADORA2AADORA1 | |
| SCHEMBL13603540 | 0.84 | ALDH1A1 (0.60) | KDM4EADORA2AHTTLMNAALDH1A1 | |
| SCHEMBL26516940 | 0.84 | KDM4E (0.56) | KDM4EADORA2AADORA1LMNAALDH1A1 | |
| SCHEMBL14959329 | 0.84 | KDM4E (0.56) | KDM4EADORA2AADORA1HTTLMNA | |
| SCHEMBL13457926 | 0.81 | HTT (0.56) | KDM4EADORA2AADORA1HTTLMNA | |
| SCHEMBL31416835 | 0.81 | KDM4E (1.00) | KDM4EHTTLMNAALDH1A1MAPT | |
| SCHEMBL221530 | 0.81 | KDM4E (1.00) | KDM4EHTTLMNAALDH1A1MAPT | |
| SCHEMBL14959257 | 0.80 | KDM4E (0.50) | KDM4EADORA2AADORA1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | claimed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | claimed |
| US-20140336182-A1 | Aurora Kinase Modulators and Method of Use | AMGEN INC (US) | 2014-11-13 | — | — | US | disclosed |
| EP-2137177-B1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |
| US-8557816-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20120122847-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088774-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2012-01-03 | — | — | US | disclosed |
| US-7981891-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2011-07-19 | — | — | US | disclosed |
| US-7888357-B2 | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death | NORTHWESTERN UNIVERSITY (US) | 2011-02-15 | — | — | US | disclosed |
| US-5716956-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | BEARSDEN BEARSDEN BIO, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| WO-1997026247-A1 | 1-ARYLPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | SYMPHONY PHARMACEUTICALS, INC. (US) | 1997-07-24 | — | — | WO | disclosed |
| US-5643911-A | CEREBROVASCULAR DISEASE | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-07-01 | — | — | US | disclosed |
| WO-1996040646-A1 | DIHYDROPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | SYMPHONY PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5462941-A | 1-(cyclohexylalkylamino)-4-(phenyl, thienyl, or furyl) phthalazines; anti-platelet agglutination agents for treatment or prevention of cerebro- or cardiovascular disorders | MITSUBISHI CHEMICAL CORPORATION (JP) | 1995-10-31 | — | — | US | disclosed |
| EP-0449203-B1 | 4-Phenylphthalazine derivatives | MITSUBISHI CHEM IND (JP) | 1994-12-07 | — | — | EP | disclosed |
| EP-0534443-A1 | 3,6-Disubstituted pyridazine derivatives | Mitsubishi Chemical Corporation (JP) | 1993-03-31 | — | — | EP | disclosed |
| US-5089494-A | 4-PHENYLPHTHALAZINE DERIVATIVES WHICH INHIBIT PLATELET AGGREGATION | MITSUBISHI KASEI CORPORATION (JP) | 1992-02-18 | — | — | US | disclosed |
| EP-0449203-A1 | 4-Phenylphthalazine derivatives | Mitsubishi Chemical Corporation (JP) | 1991-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336182-A1 | Aurora Kinase Modulators and Method of Use | AURKC, AURKA, CDK1 | KDM4E 1131/4885CSNK1A1 77/4885CLK4 339/4885 |
| US-20120122847-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AURKC, AURKA, CDK1 | KDM4E 1131/4885CSNK1A1 77/4885CLK4 339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.