Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10143654 | 0.80 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL24566941 | 0.77 | LMNA (0.58) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL31710911 | 0.77 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL38665451 | 0.77 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL974117 | 0.77 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL26859104 | 0.74 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL31710836 | 0.74 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL19678264 | 0.74 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL23613494 | 0.74 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL27965329 | 0.73 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172214-B1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2020-05-13 | — | — | EP | disclosed |