Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM6B | O15054 | 2/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.51 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.51 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21987017 | 0.88 | PLAU (0.60) | LMNASMN1; SMN2PLAUALDH1A1HPGD | |
| SCHEMBL21987042 | 0.85 | LMNA (0.53) | LMNASMN1; SMN2PLAUNPC1RAB9A | |
| SCHEMBL21987033 | 0.81 | DNMT1 (0.59) | LMNASMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL9525235 | 0.81 | ALDH1A1 (0.60) | LMNASMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL14974717 | 0.81 | ALDH1A1 (0.63) | LMNAPLAUALDH1A1HPGDKDM4E | |
| SCHEMBL9525406 | 0.81 | ALDH1A1 (0.56) | LMNASMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL21987086 | 0.80 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2PLAUNPC1RAB9A | |
| SCHEMBL9525247 | 0.79 | ALDH1A1 (0.54) | LMNASMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL7765665 | 0.78 | ANPEP (0.64) | PLAUKDM4EGSK3BHTTHDAC3 | |
| SCHEMBL14974566 | 0.78 | ALDH1A1 (0.59) | LMNAPLAUALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020109233-A2 | TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES | FORSCHUNGSZENTRUM JÜLICH GMBH FACHBEREICH PATENTE (R-P) (DE) | 2020-06-04 | — | — | WO | disclosed |
| EP-3659593-A1 | TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES | Forschungszentrum Jülich GmbH/ Abteilung RP-PT (DE) | 2020-06-03 | — | — | EP | disclosed |