Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 16/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198763 | 1.00 | CYP3A4 (0.53) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL772405 | 0.93 | CYP3A4 (0.56) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL772406 | 0.93 | CYP3A4 (0.56) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL774440 | 0.87 | CYP3A4 (0.48) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL774439 | 0.87 | CYP3A4 (0.48) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL774668 | 0.86 | PRKCA (0.42) | CYP3A4CYP2C19CYP2C9CYP2D6NR1I2 | |
| SCHEMBL772383 | 0.84 | CYP3A4 (0.56) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL772382 | 0.84 | CYP3A4 (0.56) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL771527 | 0.84 | CYP3A4 (0.62) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL771528 | 0.84 | CYP3A4 (0.62) | CYP3A4CYP2C19CYP2C9CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-20070049593-A1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049593-A1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | POLI, TERT, ZC3HAV1 | CYP3A4 1341/4885CYP2C19 1316/4885CYP2C9 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.