⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17713656 | 0.79 | LMNA (0.31) | — | |
| SCHEMBL24610598 | 0.77 | LMNA (0.44) | — | |
| SCHEMBL4407329 | 0.75 | HPGD (0.50) | — | |
| SCHEMBL28105049 | 0.75 | — | — | |
| SCHEMBL20240360 | 0.74 | LMNA (0.34) | — | |
| SCHEMBL15635867 | 0.72 | — | — | |
| SCHEMBL15894106 | 0.72 | — | — | |
| SCHEMBL24961137 | 0.72 | LMNA (0.38) | — | |
| SCHEMBL15428432 | 0.71 | CES2 (0.32) | — | |
| SCHEMBL4632592 | 0.69 | CHRM1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317271-B1 | INHIBITORS OF EZH2 (ENHANCER OF ZESTE HOMOLOG 2) | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-05-13 | — | — | EP | disclosed |