Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 10/20 | 0.38 |
| ▸ | PPARD | Q03181 | 10/20 | 0.38 |
| ▸ | PPARA | Q07869 | 10/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26083923 | 0.82 | ACHE (0.47) | CA12CA1CA9ACHE | |
| SCHEMBL2201085 | 0.81 | CA12 (0.49) | CA12CA1CA9PPARGPPARD | |
| SCHEMBL12424007 | 0.76 | PPARG (0.37) | CA12CA1CA9PPARGPPARD | |
| SCHEMBL4406390 | 0.73 | MAPT (0.46) | — | |
| SCHEMBL3523748 | 0.72 | ACHE (0.45) | CA12CA1CA9ACHE | |
| SCHEMBL2292629 | 0.71 | CA12 (0.44) | CA12CA1CA9PREP | |
| SCHEMBL2774476 | 0.70 | ACHE (0.42) | ACHE | |
| SCHEMBL9688281 | 0.70 | ALDH1A1 (0.42) | CA12CA1CA9ACHE | |
| SCHEMBL19141923 | 0.70 | ACHE (0.47) | ACHE | |
| SCHEMBL30043665 | 0.70 | CA1 (0.61) | CA12CA1CA9PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173679-B2 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERMAMEX (MC) | 2012-05-08 | — | — | US | disclosed |
| US-20110237624-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | LABORATOIRE THERAMEX (MC) | 2011-09-29 | — | — | US | disclosed |
| US-7977364-B2 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERMAMEX (MC) | 2011-07-12 | — | — | US | disclosed |
| US-7977364-B2 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERMAMEX (MC) | 2011-07-12 | — | — | US | disclosed |
| EP-1812404-B1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | THERAMEX (MC) | 2011-06-15 | — | — | EP | disclosed |
| US-20090023779-A1 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERAMEX (FR) | 2009-01-22 | — | — | US | disclosed |
| US-20090023779-A1 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERAMEX (FR) | 2009-01-22 | — | — | US | disclosed |
| EP-1812404-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | LABORATOIRE THERAMEX (MC) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006040351-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | LABORATOIRE THERAMEX (MC) | 2006-04-20 | — | — | WO | disclosed |
| EP-1647549-A1 | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents | LABORATOIRE THERAMEX (MC) | 2006-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023779-A1 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | ESR1, ESR2, GPER1 | CA12 4002/4885CA1 3146/4885CA9 2904/4885 |
| US-20110237624-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | ESR1, ESR2, GPER1 | CA12 4002/4885CA1 3146/4885CA9 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.