Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 8/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21993800 | 0.85 | KDM4E (0.43) | PPARGPPARDPPARAHTR2CKDM4E | |
| SCHEMBL5598110 | 0.81 | PPARG (0.50) | PPARGPPARDPPARATACR1KCNH2 | |
| SCHEMBL6541429 | 0.78 | TACR1 (0.46) | PPARGPPARDPPARATACR1KCNH2 | |
| SCHEMBL15118586 | 0.77 | KCNH2 (0.50) | TACR1KCNH2CYP2D6HTR1AHTR2A | |
| SCHEMBL15682813 | 0.77 | TAS1R3 (0.60) | GAA | |
| Hydrochloric Acid SCHEMBL6541423 | 0.77 | TACR1 (0.48) | PPARGPPARDPPARATACR1KCNH2 | |
| SCHEMBL15682671 | 0.76 | EPHX2 (0.56) | PPARGPPARAHTR2CKDM4E | |
| SCHEMBL22220774 | 0.75 | HCRTR1 (0.49) | PPARGPPARDPPARATACR1KCNH2 | |
| SCHEMBL17764790 | 0.75 | HSD17B10 (0.72) | PPARGPPARDPPARATACR1KCNH2 | |
| SCHEMBL15682809 | 0.74 | MAPK14 (0.59) | PPARGPPARDPPARAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220387356-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) INHIBITOR AND METHOD OF USE | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-12-08 | — | — | US | disclosed |
| US-20200147007-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) INHIBITOR AND METHOD OF USE | EASTERN MICHIGAN UNIVERSITY | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220387356-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) INHIBITOR AND METHOD OF USE | SERPINE1, PLAT, SERPINC1 | PPARG 1112/4885PPARD 1636/4885PPARA 1025/4885 |
| US-20200147007-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) INHIBITOR AND METHOD OF USE | SERPINE1, PLAT, SERPINC1 | PPARG 1112/4885PPARD 1636/4885PPARA 1025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.