Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.47 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045264 | 0.86 | TTBK1 (0.48) | TTBK1TTBK2EPHB4ATRMAPKAPK5 | |
| SCHEMBL1044297 | 0.76 | MAPKAPK5 (0.41) | TTBK1TTBK2EPHB4MAPKAPK5PIK3CA | |
| SCHEMBL12618583 | 0.74 | ATR (0.53) | TTBK1TTBK2EPHB4ATRMAPKAPK5 | |
| SCHEMBL2199773 | 0.74 | MAPKAPK5 (0.50) | TTBK1TTBK2MAPKAPK5SLC2A1 | |
| SCHEMBL1044940 | 0.70 | JAK2 (0.51) | TTBK1TTBK2MAPKAPK5PIK3CAPIK3CG | |
| SCHEMBL1043468 | 0.70 | JAK2 (0.59) | TTBK1TTBK2MAPKAPK5PIK3CAZAP70 | |
| SCHEMBL24372 | 0.70 | JAK2 (0.55) | TTBK1TTBK2EPHB4ATRPIK3CA | |
| SCHEMBL1044232 | 0.68 | AURKA (0.49) | TTBK1TTBK2MAPKAPK5JAK2SLC2A1 | |
| SCHEMBL1045483 | 0.68 | MAPKAPK5 (0.52) | TTBK1TTBK2MAPKAPK5JAK2AXL | |
| SCHEMBL2196472 | 0.68 | MAPKAPK5 (0.53) | MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977352-B2 | Triazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2011-07-12 | — | — | US | disclosed |