Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.50 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044232 | 0.84 | AURKA (0.49) | MAPKAPK5CCNKCCNA2CDK2CCND3 | |
| SCHEMBL1045288 | 0.75 | KDM1A (0.52) | MAPKAPK5CCNKCCNA2CDK2CCND3 | |
| SCHEMBL2199371 | 0.74 | TTBK1 (0.47) | MAPKAPK5SLC2A1TTBK1TTBK2 | |
| SCHEMBL1046703 | 0.74 | MAPKAPK5 (0.75) | MAPKAPK5AURKAAURKBMAPK10SYK | |
| SCHEMBL1476085 | 0.73 | MAPKAPK5 (0.64) | MAPKAPK5AURKAMAPTTSHRNR4A1 | |
| SCHEMBL1045483 | 0.72 | MAPKAPK5 (0.52) | MAPKAPK5CCNKCCNA2CDK2CCND3 | |
| SCHEMBL1045300 | 0.71 | KDM1A (0.43) | MAPKAPK5CCNKCCNA2CDK2CCND3 | |
| SCHEMBL1048653 | 0.70 | MAPKAPK5 (0.58) | MAPKAPK5MAPK10MAPK8MAPK9 | |
| SCHEMBL7980595 | 0.70 | MAPT (0.62) | MAPTSYKTTBK1TTBK2MAPK1 | |
| SCHEMBL5027836 | 0.70 | TBK1 (0.49) | CCNKCCNA2CDK2CCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977352-B2 | Triazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases | GALAPAGOS NV (BE) | 2011-07-12 | — | — | US | disclosed |