Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | PTBP1 | P26599 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | TOP2A | P11388 | 2/20 | 0.72 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 4/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9319986 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL1027017 | 0.87 | ALDH1A1 (0.77) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL10744131 | 0.85 | SMN1; SMN2 (0.73) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL9321797 | 0.84 | TOP2A (1.00) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL22056109 | 0.84 | KDM4E (0.72) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL13522800 | 0.82 | HTT (0.70) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL21994236 | 0.82 | TOP2A (0.80) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL21994247 | 0.82 | TOP2A (0.76) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL16675032 | 0.81 | ALDH1A1 (0.69) | ALDH1A1HTTKDM4EPTBP1OPRK1 | |
| SCHEMBL21994237 | 0.81 | TOP2A (0.70) | ALDH1A1HTTKDM4EPTBP1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059160-A1 | Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof | TSINGHUA UNIVERSITY (CN) | 2025-02-20 | — | — | US | claimed |
| CN-115197126-A | Novel NMNAT enzyme agonist and preparation and application thereof | 清华大学 | 2022-10-18 | — | — | CN | claimed |
| WO-2020107221-A1 | CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF | TSINGHUA UNIVERSITY (CN) | 2020-06-04 | — | — | WO | claimed |
| US-20250059160-A1 | Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof | TSINGHUA UNIVERSITY (CN) | 2025-02-20 | — | — | US | disclosed |
| CN-115197126-A | Novel NMNAT enzyme agonist and preparation and application thereof | 清华大学 | 2022-10-18 | — | — | CN | disclosed |
| WO-2020107221-A1 | CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF | TSINGHUA UNIVERSITY (CN) | 2020-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059160-A1 | Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof | NAMPT, NNMT, NAPRT | ALDH1A1 1017/4885HTT 295/4885KDM4E 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.