SCHEMBL21995259

SCHEMBL21995259

Cc1sc(Nc2cc(F)nc(F)c2)nc1C(=O)NC1CCC1(C)C

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TRPC3 Q13507 5/20 0.34
▸ TRPC6 Q9Y210 5/20 0.34
▸ TRPA1 O75762 1/20 0.34
▸ CACNA1C Q13936 1/20 0.34
▸ SCN5A Q14524 1/20 0.34
▸ TRPV1 Q8NER1 1/20 0.34
▸ TRPV4 Q9HBA0 1/20 0.34
▸ TNIK Q9UKE5 1/20 0.32
▸ DHODH Q02127 1/20 0.32
▸ CHRNA7 P36544 2/20 0.30
▸ HTR3A P46098 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31438351 1.00 TRPC3 (0.34) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL31438392 1.00 TRPC3 (0.34) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL31438386 0.92 TNIK (0.36) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL31438427 0.92 TNIK (0.36) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL22492193 0.89 TRPC3 (0.36) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL21522981 0.88 TRPC3 (0.35) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL31438347 0.88 TRPC3 (0.35) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL31438379 0.88 TRPC3 (0.35) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL31438409 0.88 TRPC3 (0.35) TRPC3TRPC6TRPA1CACNA1CSCN5A
SCHEMBL31438406 0.88 TRPC3 (0.35) TRPC3TRPC6TRPA1CACNA1CSCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11882834-B2 Microbiocidal thiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2024-01-30 — — US claimed
CN-111406055-B Microbiocidal thiazole derivatives 先正达参股股份有限公司 2023-09-22 — — CN claimed
EP-3717479-B1 MICROBIOCIDAL THIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2023-07-05 — — EP claimed
US-20210186022-A1 MICROBIOCIDAL THIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-06-24 — — US claimed
EP-3717479-A1 MICROBIOCIDAL THIAZOLE DERIVATIVES Syngenta Participations AG (CH) 2020-10-07 — — EP claimed
CN-111406055-A Microbiocidal thiazole derivatives 先正达参股股份有限公司 2020-07-10 — — CN claimed
CN-122055058-A Biaryl compound and method for controlling plant disease 住友化学株式会社 2026-05-15 — — CN disclosed
CN-122029166-A Condensed cyclic compound and harmful arthropod control composition containing the same 住友化学株式会社 2026-05-12 — — CN disclosed
CN-122029155-A Heterocyclic compound and harmful arthropod control composition containing same 住友化学株式会社 2026-05-12 — — CN disclosed
CN-115702153-B Microbiocidal derivatives 先正达农作物保护股份公司 2025-06-24 — — CN disclosed
US-12336537-B2 Fungicidal compositions SYNGENTA CROP PROTECTION AG (CH) 2025-06-24 — — US disclosed
CN-120019050-A Sulfonamide compound and harmful arthropod control composition containing same 住友化学株式会社 2025-05-16 — — CN disclosed
CN-119998283-A Sulfonamide compound and harmful arthropod control composition containing same 住友化学株式会社 2025-05-13 — — CN disclosed
US-20210186022-A1 MICROBIOCIDAL THIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-06-24 — — US disclosed
EP-3717479-A1 MICROBIOCIDAL THIAZOLE DERIVATIVES Syngenta Participations AG (CH) 2020-10-07 — — EP disclosed
CN-111406055-A Microbiocidal thiazole derivatives 先正达参股股份有限公司 2020-07-10 — — CN disclosed
WO-2020109511-A1 MICROBIOCIDAL 2-ACYLAMINO-THIAZOLE-4-CARBOXAMIDE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2020-06-04 — — WO disclosed
WO-2020109511-A1 MICROBIOCIDAL 2-ACYLAMINO-THIAZOLE-4-CARBOXAMIDE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2020-06-04 — — WO disclosed
WO-2020109509-A1 MICROBIOCIDAL THIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-06-04 — — WO disclosed
WO-2020109509-A1 MICROBIOCIDAL THIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-06-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11882834-B2 Microbiocidal thiazole derivatives MSR1, TLR1, IFNG TRPC3 927/4885TRPC6 2085/4885TRPA1 45/4885
US-20210186022-A1 MICROBIOCIDAL THIAZOLE DERIVATIVES MSR1, TLR1, IFNG TRPC3 927/4885TRPC6 2085/4885TRPA1 45/4885
US-12336537-B2 Fungicidal compositions CYP51A1, CYP4X1, CYP1B1 TRPC3 4223/4885TRPC6 4766/4885TRPA1 1550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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