Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21988725 | 0.80 | LMNA (0.40) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL21989007 | 0.79 | PTGDR (0.41) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL21988635 | 0.78 | KMT2A (0.40) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL22045989 | 0.76 | ALDH1A1 (0.41) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL21988705 | 0.76 | KDM4E (0.38) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL21988951 | 0.74 | MAPT (0.40) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL27928909 | 0.73 | LMNA (0.46) | LMNA | |
| SCHEMBL21988904 | 0.73 | HCRTR1 (0.44) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL21988657 | 0.72 | HCRTR2 (0.37) | LMNAKDM4EALDH1A1MEN1GAA | |
| SCHEMBL262384 | 0.71 | HCRTR2 (0.45) | LMNAKDM4EALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886984-A1 | PYRAZOLES AS MODULATORS OF HEMOGLOBIN | Pfizer Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020109994-A1 | PYRAZOLES AS MODULATORS OF HEMOGLOBIN | PFIZER INC. (US) | 2020-06-04 | — | — | WO | disclosed |