Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12791296 | 0.86 | P2RX7 (0.46) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL4894133 | 0.84 | NQO2 (0.49) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL506329 | 0.83 | AAK1 (0.50) | EPHX2NR1H4KDM4ABDKRB1 | |
| SCHEMBL4597727 | 0.83 | AKR1B1 (0.46) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL24791641 | 0.83 | EPHX2 (0.43) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL30193009 | 0.83 | EPHX2 (0.49) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL23832914 | 0.83 | EPHX2 (0.49) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL26828546 | 0.82 | EPHX2 (0.42) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL12231326 | 0.82 | GRM2 (0.43) | EPHX2NR1H4KDM4AKCNA5BDKRB1 | |
| SCHEMBL1495902 | 0.82 | EPHX2 (0.64) | EPHX2NR1H4KDM4AKCNA5BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886854-A1 | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | Nuvation Bio Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020113094-A1 | PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF | NUVATION BIO INC. (US) | 2020-06-04 | — | — | WO | disclosed |