Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24622151 | 1.00 | BACE1 (0.39) | BACE1BACE2NAAALIPGHDAC4 | |
| SCHEMBL24622085 | 0.94 | BACE1 (0.36) | BACE1BACE2NAAALIPGHDAC4 | |
| SCHEMBL21996508 | 0.89 | ABCB1 (0.41) | BACE1BACE2DDB1CRBN | |
| SCHEMBL24622152 | 0.89 | ABCB1 (0.41) | BACE1BACE2DDB1CRBN | |
| SCHEMBL22047122 | 0.87 | HDAC4 (0.40) | BACE1BACE2NAAALIPGHDAC4 | |
| SCHEMBL21996384 | 0.86 | BACE1 (0.39) | BACE1BACE2NAAALIPGHDAC4 | |
| SCHEMBL21996491 | 0.86 | DRD4 (0.35) | BACE1BACE2DDB1CRBN | |
| SCHEMBL22047547 | 0.86 | DRD4 (0.35) | BACE1BACE2DDB1CRBN | |
| SCHEMBL21996651 | 0.84 | BACE1 (0.38) | BACE1BACE2NAAALIPGHDAC4 | |
| SCHEMBL16434872 | 0.80 | BACE1 (0.49) | BACE1BACE2NAAALIPGDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020113077-A9 | COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020113077-A1 | COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-06-04 | — | — | WO | disclosed |