Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Thiamine Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | TKT | P29401 | 11/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiamine Ion SCHEMBL16829706 | 0.99 | HSP90AA1 (0.85) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL16829707 | 0.98 | HSP90AA1 (0.87) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL29195374 | 0.98 | HSP90AA1 (0.87) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL27512143 | 0.96 | HSP90AA1 (0.83) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL27555400 | 0.96 | HSP90AA1 (0.83) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL23151788 | 0.95 | HSP90AA1 (0.82) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL28869571 | 0.95 | HSP90AA1 (0.82) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL4604194 | 0.95 | HSP90AA1 (0.85) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL7090274 | 0.94 | HSP90AA1 (0.98) | HSP90AA1TDP1TKTKDM4ELMNA | |
| Thiamine Ion SCHEMBL29445547 | 0.94 | HSP90AA1 (0.98) | HSP90AA1TDP1TKTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 355 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119873874-A | Monodisperse copper sulfide quantum dot and preparation method and application of nano composite material thereof | 周口师范学院 | 2025-04-25 | — | — | CN | claimed |
| CN-116602408-B | Microecological extract containing angelica keiskei koidzumi polypeptide, and preparation method and application thereof | 深圳中科生物药业有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-118872777-A | Chicken feed for improving vitamin D content of eggs and preparation method thereof | 麦蛋(广州)农业食品有限公司 | 2024-11-01 | — | — | CN | claimed |
| CN-117756796-A | Method for preparing thiamine nitrate or thiamine hydrochloride by direct oxidation of thiamine hydrochloride and application thereof | 江苏兄弟维生素有限公司 | 2024-03-26 | — | — | CN | claimed |
| CN-117398387-A | Use of thiamine or derivatives thereof against microgravity-induced cardiovascular diseases | 苏州大学 | 2024-01-16 | — | — | CN | claimed |
| US-11834425-B2 | Full continuous-flow preparation method of vitamin B1 | FUDAN UNIVERSITY (CN) | 2023-12-05 | — | — | US | claimed |
| CN-116602408-A | Microecological extract containing angelica keiskei koidzumi polypeptide, and preparation method and application thereof | 深圳中科生物药业有限公司 | 2023-08-18 | — | — | CN | claimed |
| CN-114181203-B | Preparation method of thiamine hydrochloride, application and vitamin B1 | 江苏兄弟维生素有限公司 | 2023-08-18 | — | — | CN | claimed |
| CN-116478151-A | Method for optimizing thiamine nitrate crystallization process | 浙江工业大学 | 2023-07-25 | — | — | CN | claimed |
| CN-116283952-A | Vitamin B 1 Is a fully continuous flow preparation method | 复旦大学 | 2023-06-23 | — | — | CN | claimed |
| US-20230183196-A1 | FULL CONTINUOUS-FLOW PREPARATION METHOD OF VITAMIN B1 | FUDAN UNIVERSITY (CN) | 2023-06-15 | — | — | US | claimed |
| CN-115428958-A | Composite polypeptide powder and preparation method thereof | 善元健康管理(大连)有限公司 | 2022-12-06 | — | — | CN | claimed |
| CN-114181203-A | Preparation method of thiamine hydrochloride, application and vitamin B1 | 江苏兄弟维生素有限公司 | 2022-03-15 | — | — | CN | claimed |
| CN-112806437-A | High-protein probiotic solid beverage and preparation method thereof | 广州景腾医疗科技有限公司 | 2021-05-18 | — | — | CN | claimed |
| CN-111406950-A | Composite polypeptide powder | 北京大元藏宝堂健康管理有限公司 | 2020-07-14 | — | — | CN | claimed |
| CN-111004230-A | Thiamine hydrochloride, its synthesis method and medicine | 江苏兄弟维生素有限公司 | 2020-04-14 | — | — | CN | claimed |
| CN-110574686-A | In-vitro cultivation method of Dendrobium Nanyue | 永州职业技术学院 | 2019-12-17 | — | — | CN | claimed |
| JP-58023766-A | — | — | None | — | — | JP | disclosed |
| EP-1043028-A1 | METHOD FOR PREVENTING/REMEDYING MASTITIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-10-11 | — | — | EP | disclosed |
| JP-S5823766-A | COLORING OF MEAT OF ANIMAL, BIRD, OR FISH | HARADA HIDEHIRO | 1983-02-12 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183196-A1 | FULL CONTINUOUS-FLOW PREPARATION METHOD OF VITAMIN B1 | SLC19A2, VKORC1, VKORC1L1 | HSP90AA1 3116/4885TDP1 4866/4885TKT 860/4885 |
| US-11834425-B2 | Full continuous-flow preparation method of vitamin B1 | SLC19A2, CYP2S1, CBS | HSP90AA1 3137/4885TDP1 4551/4885TKT 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.