Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250466 | 0.70 | CYP1A2 (0.40) | ALDH1A1CYP1A2TSHR | |
| SCHEMBL1643331 | 0.69 | USP2 (0.42) | MMEALDH1A1LMNAUSP2CYP1A2 | |
| SCHEMBL15730431 | 0.68 | — | — | |
| SCHEMBL21997572 | 0.67 | CTSL (0.34) | MMEALDH1A1LMNAHPGD | |
| Ethylenediamine SCHEMBL1929819 | 0.66 | GABRR1 (0.42) | ALDH1A1LMNATSHRCACNA2D1HPGD | |
| Ethylenediamine SCHEMBL1929817 | 0.66 | GABRR1 (0.42) | ALDH1A1LMNATSHRCACNA2D1HPGD | |
| SCHEMBL6519091 | 0.66 | — | — | |
| SCHEMBL27647180 | 0.64 | USP2 (0.45) | MMEALDH1A1LMNAUSP2CYP1A2 | |
| SCHEMBL22338035 | 0.64 | — | — | |
| SCHEMBL15730444 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886904-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020113233-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |