Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 7/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840862 | 0.69 | ALDH1A1 (0.37) | ALDH1A1CTSKMME | |
| SCHEMBL12908851 | 0.68 | — | — | |
| SCHEMBL21998138 | 0.67 | MME (0.33) | LMNAHPGDALDH1A1MME | |
| SCHEMBL17294312 | 0.66 | TP53 (0.32) | ALDH1A1MAPT | |
| SCHEMBL840305 | 0.66 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL3817810 | 0.64 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL10177532 | 0.64 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL3362836 | 0.63 | TRPA1 (0.35) | CTSLLMNAHPGD | |
| SCHEMBL3741243 | 0.63 | HRH3 (0.33) | — | |
| SCHEMBL2862634 | 0.63 | ALDH1A1 (0.34) | LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886904-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020113233-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |