Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26690300 | 0.83 | ALDH1A1 (0.38) | EPHX2ALDH1A1EPHX1MAPK1HCAR2 | |
| SCHEMBL9537184 | 0.82 | MEN1 (0.40) | MEN1KMT2AEPHX2ALDH1A1HCAR2 | |
| SCHEMBL11229001 | 0.75 | CYP3A4 (0.37) | MEN1KMT2AEPHX2ALDH1A1DPP4 | |
| SCHEMBL8781565 | 0.75 | ALDH1A1 (0.40) | MEN1KMT2AEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11225149 | 0.70 | NAAA (0.38) | EPHX2EPHX1GAAMAPK1HTT | |
| SCHEMBL11229711 | 0.70 | NAAA (0.38) | EPHX2EPHX1GAAMAPK1HTT | |
| SCHEMBL11225142 | 0.70 | NAAA (0.38) | EPHX2EPHX1GAAMAPK1HTT | |
| SCHEMBL27216297 | 0.69 | CYP3A4 (0.37) | MEN1KMT2AEPHX2ALDH1A1DPP4 | |
| SCHEMBL21998276 | 0.69 | MEN1 (0.36) | MEN1KMT2AEPHX2ALDH1A1EPHX1 | |
| SCHEMBL28217615 | 0.69 | CYP4F2 (0.41) | EPHX2EPHX1GAAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3886904-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020113233-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-06-04 | — | — | WO | disclosed |