Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29528202 | 0.93 | TGFBR1 (0.49) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 | |
| SCHEMBL21932036 | 0.93 | TGFBR1 (0.49) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 | |
| Hydrochloric Acid SCHEMBL21932094 | 0.92 | TGFBR1 (0.48) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 | |
| SCHEMBL22822809 | 0.89 | TGFBR1 (0.40) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 | |
| SCHEMBL29528228 | 0.83 | TGFBR1 (0.41) | TGFBR1ACVR1B | |
| SCHEMBL21932018 | 0.83 | TGFBR1 (0.41) | TGFBR1ACVR1B | |
| SCHEMBL21932037 | 0.78 | TGFBR1 (0.66) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 | |
| SCHEMBL410420 | 0.78 | TGFBR1 (0.67) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 | |
| SCHEMBL23873733 | 0.77 | CYP1A2 (0.44) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 | |
| SCHEMBL373364 | 0.75 | TGFBR1 (0.70) | TGFBR1ACVR1BCYP1A2CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230132568-A1 | ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES | SYNTHIS THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | US | disclosed |
| US-11583593-B2 | Antibody-ALK5 inhibitor conjugates and their uses | SYNTHIS THERAPEUTICS, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-20200147234-A1 | ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES | SYNTHIS, LLC (US) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11583593-B2 | Antibody-ALK5 inhibitor conjugates and their uses | ALK, ALKBH5, ALKBH3 | TGFBR1 528/4885ACVR1B 33/4885CYP1A2 2565/4885 |
| US-20200147234-A1 | ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES | ALK, ALKBH5, ALKBH3 | TGFBR1 528/4885ACVR1B 33/4885CYP1A2 2565/4885 |
| US-20230132568-A1 | ANTIBODY-ALK5 INHIBITOR CONJUGATES AND THEIR USES | ALK, ALKBH5, ALKBH3 | TGFBR1 528/4885ACVR1B 33/4885CYP1A2 2565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.