Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.31 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194894 | 0.94 | ATM (0.37) | CYP2A6ATMSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL2198138 | 0.86 | CYP2A6 (0.46) | CYP2A6SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL2198969 | 0.86 | CYP2A6 (0.41) | CYP2A6ATMSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL29360928 | 0.85 | ATM (0.39) | ATMSMN1; SMN2LMNAL3MBTL1MAPK14 | |
| SCHEMBL3114118 | 0.85 | ATM (0.39) | ATMSMN1; SMN2LMNAL3MBTL1MAPK14 | |
| SCHEMBL2444825 | 0.85 | ATM (0.39) | ATMSMN1; SMN2LMNAL3MBTL1MAPK14 | |
| SCHEMBL29369392 | 0.85 | ATM (0.39) | ATMSMN1; SMN2LMNAL3MBTL1MAPK14 | |
| SCHEMBL2471057 | 0.85 | ATM (0.39) | ATMSMN1; SMN2LMNAL3MBTL1MAPK14 | |
| SCHEMBL29367523 | 0.85 | ATM (0.39) | ATMSMN1; SMN2LMNAL3MBTL1MAPK14 | |
| SCHEMBL2444831 | 0.85 | ATM (0.39) | ATMSMN1; SMN2LMNAL3MBTL1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998983-B2 | 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethysilylisoxazole; crop protection agents to combat or prevent fungal infestations, or to control other pests such as weeds, insects, or acarids | SYNGENTA LIMITED (GB) | 2011-08-16 | — | — | US | claimed |
| WO-2013011010-A1 | FUNGIZIDE MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-24 | — | — | WO | disclosed |
| WO-2013011010-A1 | FUNGIZIDE MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-24 | — | — | WO | disclosed |
| WO-2013007550-A1 | FUNGICIDE MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-17 | — | — | WO | disclosed |
| WO-2013007550-A1 | FUNGICIDE MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-01-17 | — | — | WO | disclosed |
| US-20110251066-A1 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-10-13 | — | — | US | disclosed |
| US-20110251066-A1 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-10-13 | — | — | US | disclosed |
| US-20110251066-A1 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA CROP PROTECTION LLC (US) | 2011-10-13 | — | — | US | disclosed |
| EP-2369933-A2 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | Syngenta Participations AG (CH) | 2011-10-05 | — | — | EP | disclosed |
| US-7998983-B2 | 3-(2,6-Dichlorophenyl)-4-[(3-pyridyl)hydroxymethyl]-5-trimethysilylisoxazole; crop protection agents to combat or prevent fungal infestations, or to control other pests such as weeds, insects, or acarids | SYNGENTA LIMITED (GB) | 2011-08-16 | — | — | US | disclosed |
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | SYNGENTA LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | SYNGENTA LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | SYNGENTA LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-7338967-B2 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2008-03-04 | — | — | US | disclosed |
| US-7338967-B2 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2008-03-04 | — | — | US | disclosed |
| EP-1794167-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | Syngenta Limited (GB) | 2007-06-13 | — | — | EP | disclosed |
| US-20060073971-A1 | Substituted isoxazoles as fungicides | SYNGENTA LIMITED (GB) | 2006-04-06 | — | — | US | disclosed |
| WO-2006031631-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167350-A1 | SUBSTITUTED ISOXAZOLES AS FUNGICIDES | CYP4X1, CYP51A1, CYP3A7 | CYP2A6 84/4885ATM 3478/4885SMN1; SMN2 2136/4885 |
| US-20080096843-A1 | Substituted Isoxazoles as Fungicides | CYP4X1, CYP51A1, CYP3A7 | CYP2A6 97/4885ATM 3589/4885SMN1; SMN2 2387/4885 |
| US-20110251066-A1 | ISOXAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | CYP4Z1, CYP4X1, AGXT | CYP2A6 1430/4885ATM 2678/4885SMN1; SMN2 4879/4885 |
| US-20060073971-A1 | Substituted isoxazoles as fungicides | CYP4X1, CYP51A1, CYP3A7 | CYP2A6 96/4885ATM 3256/4885SMN1; SMN2 2646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.